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Frequently Asked Questions

RESTASIS® and RESTASIS MultiDose™ Product Information

What is RESTASIS®?

RESTASIS® (also available as RESTASIS MultiDose™) is the only prescription medication
proven to help you make more of your own real tears. RESTASIS® and RESTASIS MultiDose™ helps increase your eyes’ natural ability to produce tears, which may be reduced by inflammation due to Chronic Dry Eye disease. RESTASIS® and RESTASIS MultiDose™ did not increase tear production in patients using anti-inflammatory eye drops or tear duct plugs.

Is RESTASIS MultiDose™ a different medicine from RESTASIS®?

No. RESTASIS MultiDose™ is the same RESTASIS® formulation doctors have prescribed
6.4 million times since 2003.* The RESTASIS MultiDose™ patented bottle design allows the preservative-free formulation to be packaged in a bottle. RESTASIS MultiDose™ is the only FDA- approved, preservative-free prescription eye drop in a bottle.

How is RESTASIS MultiDose™ different from RESTASIS®?

While RESTASIS MultiDose™ is the same RESTASIS® formulation doctors have prescribed
6.4 million times since 2003,* its patented bottle design allows the preservative-free formulation
to be packaged in a bottle. Only RESTASIS® gives you the convenience to choose between a multidose bottle or single-use vials. RESTASIS MultiDose™ is the only FDA-approved, preservative-free prescription eye drop in a bottle.

What should I know about RESTASIS® and RESTASIS MultiDose™?

RESTASIS® and RESTASIS MultiDose™ are the only prescription medications FDA approved to help you make more of your own tears. With the introduction of RESTASIS MultiDose™, only RESTASIS® gives you the convenience to choose between a multidose bottle or single-use vials.

Why should I consider switching from RESTASIS® to RESTASIS MultiDose™?
If you prefer your eye drops in a bottle, RESTASIS MultiDose™ may be a great option. It's the same preservative-free RESTASIS® formulation doctors have prescribed 6.4 million times since 2003,* in a patented bottle design. Compared to RESTASIS® single-use vials, RESTASIS MultiDose™ is more compact, uses less plastic in packaging, and is the same price in comparison to a package of single-use vials.

Who can prescribe RESTASIS® and RESTASIS MultiDose™?

Any physician can prescribe RESTASIS® and RESTASIS MultiDose™.

What can I expect with RESTASIS® or RESTASIS MultiDose™?

Making more of your own real tears is a real possibility when you give RESTASIS® or
RESTASIS MultiDose™ time. In a 6-month study, patients made significantly more of their own real tears. Individual results may vary.

How often should I use RESTASIS® or RESTASIS MultiDose™?

Use 1 drop of RESTASIS® or RESTASIS MultiDosetwice a day in each eye,
12 hours apart—every day.

What happens if I get more than 1 drop of RESTASIS® or RESTASIS MultiDose
in my eyes?

Please contact your eye doctor if you have questions regarding the proper use of RESTASIS®
or RESTASIS MultiDose™.

What are the side effects of RESTASIS® and RESTASIS MultiDose™?

You may experience some temporary burning and stinging. This may be a response to treatment. If you have concerns, or this persists, follow up with your eye doctor immediately. Other side effects include eye redness, discharge, watery eyes, eye pain, foreign body sensation, itching, stinging, and blurred vision. Talk to your eye doctor, and see the Important Safety Information and the full Product Information to learn more.

Who should not use RESTASIS® and RESTASIS Multidose™?

Do not use RESTASIS® or RESTASIS MultiDose™ if you are allergic to any of the ingredients. Talk to your eye doctor, and see the Important Safety Information and the full Product Information to learn more.

Can I use RESTASIS® or RESTASIS MultiDose™ with other medications?

Be sure to tell your eye doctor about any other medications you use. RESTASIS® or
RESTASIS MultiDose™ can be used with artificial tears as long as you wait 15 minutes
between products.

How long will I have to use RESTASIS® or RESTASIS MultiDose™?

Chronic Dry Eye disease is a treatable but chronic condition with no permanent cure. As long as you continuously use RESTASIS® or RESTASIS MultiDose™, as prescribed by your eye doctor, you may continue to make more of your own real tears. Individual results may vary.

What will happen if I just stop taking RESTASIS® or RESTASIS MultiDose™?

Any increase in real tears you notice with RESTASIS® or RESTASIS MultiDose™ will only
continue if you continue to use RESTASIS® or RESTASIS MultiDose™ correctly: twice a day, every day, approximately 12 hours apart.

If I wear contact lenses, can I use RESTASIS® or RESTASIS MultiDose™?

Yes, you can use RESTASIS® or RESTASIS MultiDose™ if you wear contact lenses. Your contact lenses should be removed prior to use of RESTASIS® or RESTASIS MultiDose™ and may be put back in after 15 minutes.

How are RESTASIS® and RESTASIS MultiDose™ different from artificial tears?

RESTASIS® and RESTASIS MultiDose™ are not artificial tears. Both are prescription
medications. Artificial tears provide temporary relief, but can’t help you make more of your own tears; only prescription RESTASIS® or RESTASIS MultiDose™ can do that. RESTASIS® and RESTASIS MultiDose™ did not increase tear production in patients using anti-inflammatory eye drops or tear duct plugs.

Can RESTASIS® and RESTASIS MultiDose™ be used with artificial tears?

Yes. Continue to use artificial tears as needed for temporary relief, leaving 15 minutes between products. Over time with RESTASIS® or RESTASIS MultiDose™, you may rely less on artificial tears. Individual results may vary.

How can I get RESTASIS MultiDose™?

If you are already using RESTASIS®, simply ask your doctor for RESTASIS MultiDose™ at your next visit.

If you are not currently using RESTASIS® or RESTASIS MultiDose™, make an appointment with your eye doctor and ask if RESTASIS MultiDose™ is right for you.

If I choose to use single-use vials, are they still available?

Yes. Only RESTASIS® gives you the convenience to choose between a bottle of RESTASIS
MultiDose
™ or RESTASIS® packaged in single-use vials.

Is RESTASIS MultiDose™ more expensive than RESTASIS® in single-use vials?

No. RESTASIS MultiDose™ is the same price as RESTASIS® single-use vials.

Is RESTASIS MultiDose™ available as a 90-day prescription?

Yes, you will receive three 5.5-mL multidose bottles, which are intended for a 90-day supply.

Can I use RESTASIS® or RESTASIS MultiDose™ if I have tear duct plugs?

RESTASIS® and RESTASIS MultiDose™ did not increase tear production in patients using
anti-inflammatory eye drops or tear duct plugs.

Will RESTASIS® or RESTASIS MultiDose™ work as intended if I have had cataract
surgery?

Talk to your optometrist or ophthalmologist to find out if RESTASIS® or RESTASIS MultiDose
is right for you.

How do I take the cap off the RESTASIS MultiDose™ bottle?

Clear Shipping Cover:
First, pull off the clear shipping cover that rests over the cap by pulling straight up. Throw the shipping cover away.

Green Protective Cap:
Next, remove the pull tab on the green colored protective cap by pulling the end of the pull
tab away from the bottle then winding it counterclockwise. Throw away the pull tab.

Now you can remove the green colored protective cap by pulling it straight up. Keep the
colored protective cap.

Click here for instructions on how to use the RESTASIS MultiDose™ bottle.

Why should I throw away a vial after I have used it if there is still solution left in the vial?

RESTASIS® is packaged in single-use vials because it does not contain preservatives. Use 1
vial each time, and immediately discard after use.

Can I use RESTASIS® for more than 1 dose if I store it in the refrigerator?

No. RESTASIS® is packaged in single-use vials because it does not contain any preservatives. So, it is important that 1 vial be used each time and immediately discarded after each use. If you would prefer to not discard leftover medication, ask for RESTASIS MultiDose™. It is the same RESTASIS® formulation in a bottle. The patented RESTASIS MultiDose™ is the only FDA-
approved, preservative-free medication in a bottle.

Can I use RESTASIS® or RESTASIS MultiDose™ if it is beyond its shelf life or
past the expiration date?

According to the US Food and Drug Administration (FDA), if your medicine has expired, it may not provide the treatment you need. Talk to your pharmacist or eye doctor for specific advice.

Are RESTASIS® and RESTASIS MultiDose™ gluten-free?

Yes. RESTASIS® and RESTASIS MultiDose™ do not contain corn, wheat, oats, barley, rye,
spelt, or ingredients derived therefrom.

What are the ingredients in RESTASIS® and RESTASIS MultiDose™?

Each milliliter (mL) contains an active ingredient of cyclosporine 0.05% and inactive ingredients of glycerin, castor oil, polysorbate 80, carbomer copolymer type A, purified water, and sodium hydroxide to adjust pH.

Can RESTASIS® vials be recycled?

Yes. They are recycle code #4.

Can the RESTASIS MultiDose™ bottle be recycled?

Yes. It is recycle code #4. The new RESTASIS MultiDose™ bottle also uses less plastic than a
package of single-use vials, so there is less plastic that has to be recycled.


*RESTASIS® (single-use vials) Projected Patient Counts, SOW 2016-04


Go to next page: RESTASIS® and RESTASIS MultiDose™ Insurance and Cost Information

Approved Use
RESTASIS® and RESTASIS
MultiDose™
Ophthalmic Emulsion
help increase your eyes’ natural
ability to produce tears, which may
be reduced by inflammation due to
Chronic Dry Eye. RESTASIS® and
RESTASIS MultiDose™ did not
increase tear production in patients
using anti-inflammatory eye drops
or tear duct plugs.

Important Safety Information
Do not use RESTASIS® and
RESTASIS MultiDose™ Ophthalmic
Emulsion if you are allergic to any
of the ingredients. Be careful not to
touch the container tip to your eye
or other surfaces, to help avoid eye
injury and contamination.
See more below >